Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect

Nusrat Shams; Monir Hossain; Mahfuza Shirin; Husnea Ara Khan; Mohammad Mohsin

doi:doi:10.11648/j.ajp.20230903.20

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Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect

Nusrat Shams, Monir Hossain, Mahfuza Shirin, Husnea Ara Khan, Mohammad Mohsin

Published in American Journal of Pediatrics (Volume 9, Issue 3)

Received: 10 June 2023 Accepted: 4 July 2023 Published: 22 August 2023

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Abstract

Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.

Published in	American Journal of Pediatrics (Volume 9, Issue 3)
DOI	10.11648/j.ajp.20230903.20
Page(s)	164-170
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Periconceptional Lifestyle, Birth-Defect, Anomaly, Causative Factors

References

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APA Style

Nusrat Shams, Monir Hossain, Mahfuza Shirin, Husnea Ara Khan, Mohammad Mohsin. (2023). Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. American Journal of Pediatrics, 9(3), 164-170. https://doi.org/10.11648/j.ajp.20230903.20

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ACS Style

Nusrat Shams; Monir Hossain; Mahfuza Shirin; Husnea Ara Khan; Mohammad Mohsin. Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. Am. J. Pediatr. 2023, 9(3), 164-170. doi: 10.11648/j.ajp.20230903.20

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AMA Style

Nusrat Shams, Monir Hossain, Mahfuza Shirin, Husnea Ara Khan, Mohammad Mohsin. Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. Am J Pediatr. 2023;9(3):164-170. doi: 10.11648/j.ajp.20230903.20

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@article{10.11648/j.ajp.20230903.20,
  author = {Nusrat Shams and Monir Hossain and Mahfuza Shirin and Husnea Ara Khan and Mohammad Mohsin},
  title = {Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {3},
  pages = {164-170},
  doi = {10.11648/j.ajp.20230903.20},
  url = {https://doi.org/10.11648/j.ajp.20230903.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230903.20},
  abstract = {Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.},
 year = {2023}
}

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TY  - JOUR
T1  - Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect
AU  - Nusrat Shams
AU  - Monir Hossain
AU  - Mahfuza Shirin
AU  - Husnea Ara Khan
AU  - Mohammad Mohsin
Y1  - 2023/08/22
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230903.20
DO  - 10.11648/j.ajp.20230903.20
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 164
EP  - 170
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230903.20
AB  - Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.
VL  - 9
IS  - 3
ER  -

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Author Information

Nusrat Shams

Department of Paediatrics, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh
Monir Hossain

Department of Critical Care Paediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh
Mahfuza Shirin

Department of Critical Care Paediatrics, Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh
Husnea Ara Khan

Department of Paediatrics, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh
Mohammad Mohsin

Department of Paediatrics, Kuwait Bangladesh Friendship Government Hospital, Dhaka, Bangladesh

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APA Style

Nusrat Shams, Monir Hossain, Mahfuza Shirin, Husnea Ara Khan, Mohammad Mohsin. (2023). Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. American Journal of Pediatrics, 9(3), 164-170. https://doi.org/10.11648/j.ajp.20230903.20

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ACS Style

Nusrat Shams; Monir Hossain; Mahfuza Shirin; Husnea Ara Khan; Mohammad Mohsin. Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. Am. J. Pediatr. 2023, 9(3), 164-170. doi: 10.11648/j.ajp.20230903.20

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AMA Style

Nusrat Shams, Monir Hossain, Mahfuza Shirin, Husnea Ara Khan, Mohammad Mohsin. Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect. Am J Pediatr. 2023;9(3):164-170. doi: 10.11648/j.ajp.20230903.20

Copy | Download

@article{10.11648/j.ajp.20230903.20,
  author = {Nusrat Shams and Monir Hossain and Mahfuza Shirin and Husnea Ara Khan and Mohammad Mohsin},
  title = {Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {3},
  pages = {164-170},
  doi = {10.11648/j.ajp.20230903.20},
  url = {https://doi.org/10.11648/j.ajp.20230903.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230903.20},
  abstract = {Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.},
 year = {2023}
}

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TY  - JOUR
T1  - Effect of Periconceptional Life Style Factors on Occurrence of Birth Defect
AU  - Nusrat Shams
AU  - Monir Hossain
AU  - Mahfuza Shirin
AU  - Husnea Ara Khan
AU  - Mohammad Mohsin
Y1  - 2023/08/22
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230903.20
DO  - 10.11648/j.ajp.20230903.20
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 164
EP  - 170
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230903.20
AB  - Globally, birth defects (BDs) affect approximately 3-5% of infants and can arise during intrauterine life, remaining present at birth regardless of whether they are immediately recognized. These defects can be caused by a variety of factors, including chromosomal anomalies, multifactorial etiology, single gene disorders, and environmental influences; however, the cause remains unknown in many cases. Among the various causes, periconceptional factors play a crucial role in influencing the critical period of organogenesis. Therefore, the aim of this case-control study conducted at the Pediatric Surgery and Medicine Department in Dhaka Shishu (Children) Hospital, Bangladesh, from January 2012 to December 2013 was to assess the impact of periconceptional lifestyle factors on the occurrence of birth defects. The study included 280 infants aged 0-364 days, with an equal number of cases presenting structural birth defects and controls without any birth defects. Detailed examinations and relevant investigations were conducted for each subject, and data analysis was performed using SPSS 16.0 version through univariate, bivariate, and multivariate analyses, with results presented in tables and graphs. The study revealed significant associations between birth defects and several lifestyle factors, including advanced parental age (>30 years), parental illiteracy, maternal low BMI, low socio-economic condition, rural residency, paternal insecticide exposure, prolonged sunlight exposure, parental tobacco exposure in various forms, use of coal stove for cooking, and inadequate dietary intake of meat, fish, milk, egg, and pulses. These findings emphasize the importance of preventive measures through pre-conceptional and periconceptional care to modify these lifestyle factors and reduce the incidence of birth defects.
VL  - 9
IS  - 3
ER  -

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